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The Determination of the Effect of Volatile Anesthetics on Leukocyte Function ex Vivo

NCT ID: NCT02207842

Last Updated: 2017-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

41 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-11-30

Study Completion Date

2017-01-31

Brief Summary

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One of the most common side effects of a surgical procedure is infection. In order to lower the number of infections that occur after surgery, it is important for physicians to know how medications used during surgery affect the way the body fights infection. Often, when anesthesiologists are helping people go to sleep before surgery they give people medications known as "volatile anesthetics". Volatile anesthetics are medications that can change from a liquid or solid to a gas very easily. Some studies suggest that these types of medications may change the way white blood cells work in the body. Changing the way white blood cells work could possibly increase the person's risk of infection after their surgery or weaken their body's ability to fight infections. The goal of this research study is to learn about how volatile anesthesia medications change the way white blood cells work in people having anesthesia for cardiac procedures. To do this, investigators will examine the function of while blood cells in the laboratory based setting.

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Detailed Description

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Conditions

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Leukocyte Function Anesthesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Volatile anesthesia exposure

No interventions assigned to this group

No volatile anesthesia exposure

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Male and female patients
* greater than or equal to 12 months of age
* scheduled for a cardiac catheterization, cardiac surgery, or cardiac MRI

Exclusion Criteria

* known underlying hematological disorder
* known oncological disorder
* patients who do not require preoperative laboratory testing
Minimum Eligible Age

12 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Koichi Yuki

staff anesthesiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Koichi Yuki, M.D.

Role: PRINCIPAL_INVESTIGATOR

Boston Children's Hospital

Locations

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Boston Children's Hospital

Boston, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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P00012751

Identifier Type: -

Identifier Source: org_study_id

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