Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery
NCT ID: NCT01452256
Last Updated: 2016-02-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE4
460 participants
INTERVENTIONAL
2011-12-31
2014-12-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a group of general anesthetics. Because of the hypnotic effects of these agents, attention has mainly focused on the central nervous system. In the last 10 years, however, numerous studies have reported that volatile anesthetic agents interact with membrane structures of the myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte. Anesthetic-induced preconditioning has become a main topic in cardiac research worldwide
* Trial with medicinal product
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effects of Desflurane and Propofol During Lung Volume Reduction Surgery
NCT04226625
Efficacy of Propofol vs Placebo in the Prevention of Coughing During Emergence of General Anesthesia Under Desflurane
NCT02932397
Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
NCT03209193
The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung
NCT04645316
The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery
NCT05331027
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Desflurane
Desflurane for pharmacological conditioning
Desflurane
4-6 Vol %
Propofol
Propofol
TIVA to achieve BIS value of 40-60
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Desflurane
4-6 Vol %
Propofol
TIVA to achieve BIS value of 40-60
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* One-lung ventilation
* Adults (18-80 years of age)
* ASA classification I - III
* Written consent (signature from patient)
Exclusion Criteria
* Known hypersensitivity to volatile anesthetics (malignant hyperthermia)
* Medication with high dosage of statins
* Therapy with cyclosporin
* Severe renal impairment (GFR \< 30 ml/min)
* Oral steroid treatment at present or stopped less than 3 months before surgery
* Inflammatory processes (non-pulmonary or pulmonary): elevated C-reactive protein level (\> 20 mg/l) or leukocytosis (leukocytes \> 10x103/?l) or body temperature \> 37°C)
* Pregnancy
* Breast feeding
* The subject must not be involved in any other clinical trial during the course of this trial, nor within a period of 30 days prior to its beginning or 30 days after its completion
18 Years
80 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Cantonal Hospital of St. Gallen
OTHER
Kantonsspital Münsterlingen
OTHER
University Hospital, Basel, Switzerland
OTHER
Insel Gruppe AG, University Hospital Bern
OTHER
University of Zurich
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
01 Studienregister MasterAdmins
Role: STUDY_DIRECTOR
UniversitaetsSpital Zuerich
Beatrice Beck Schimmer, Professor
Role: PRINCIPAL_INVESTIGATOR
University Hospital Zurich, Division of Anaesthesiology
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University Hospital Zurich
Zurich, , Switzerland
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Neff TA, Braun J, Rana D, Puhan M, Filipovic M, Seeberger M, Stuber F, Neff SB, Beck-Schimmer B, Schlapfer M. Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery: Exploratory Results From a Substudy of a Randomized Controlled Multicenter Trial. Anesth Analg. 2022 Jan 1;134(1):123-132. doi: 10.1213/ANE.0000000000005639.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
KEK-ZH Nr.2011-0092
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.