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Desflurane Versus Propofol in the Sitting Position

NCT ID: NCT01436799

Last Updated: 2013-09-09

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-08-31

Brief Summary

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The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.

Detailed Description

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The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

Conditions

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Cerebral Ischemia

Keywords

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propofol desflurane cerebrovascular circulation sitting

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Investigators

Study Groups

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Desflurane

anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

anaesthesia was maintained by desflurane 4-7vol%

alfentanil

Intervention Type DRUG

administration of alfentanil 10 μg kg-1 for anesthetic induction

Rocuronium

Intervention Type DRUG

administration of rocuronium 0.6 mg kg-1 for anesthetic induction

propofol

anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model

Group Type ACTIVE_COMPARATOR

propofol

Intervention Type DRUG

anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly.

alfentanil

Intervention Type DRUG

administration of alfentanil 10 μg kg-1 for anesthetic induction

Rocuronium

Intervention Type DRUG

administration of rocuronium 0.6 mg kg-1 for anesthetic induction

Interventions

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propofol

anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly.

Intervention Type DRUG

Desflurane

anaesthesia was maintained by desflurane 4-7vol%

Intervention Type DRUG

alfentanil

administration of alfentanil 10 μg kg-1 for anesthetic induction

Intervention Type DRUG

Rocuronium

administration of rocuronium 0.6 mg kg-1 for anesthetic induction

Intervention Type DRUG

Other Intervention Names

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Des alf roc

Eligibility Criteria

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Inclusion Criteria

* Forty patients,
* ASA class I or II,
* undergoing shoulder arthroscopy

Exclusion Criteria

* Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index \> 30) were excluded from this study.
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gachon University Gil Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Hyun Jeong Kwak

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hyun Jeong Kwak, MD.PhD

Role: STUDY_DIRECTOR

Gachon University Gil Medical Center

Other Identifiers

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GIRBA2466

Identifier Type: -

Identifier Source: org_study_id