Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

62 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2014-03-31

Brief Summary

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It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.

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Detailed Description

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Conditions

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Deep Extubation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Desflurane group

1.5 MAC desflurane until extubation

Group Type ACTIVE_COMPARATOR

Desflurane

Intervention Type DRUG

During the emergence from anesthesia,extubation was performed under 1.5 MAC desflurane

Desflurane with remifentanil group

1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil

Group Type ACTIVE_COMPARATOR

Desflurane with remifentanil

Intervention Type DRUG

During the emergence from anesthesia,extubation was performed under 1.0 MAC desflurane with 1.0ng/ml remifentanil

Interventions

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Desflurane with remifentanil

During the emergence from anesthesia,extubation was performed under 1.0 MAC desflurane with 1.0ng/ml remifentanil

Intervention Type DRUG

Desflurane

During the emergence from anesthesia,extubation was performed under 1.5 MAC desflurane

Intervention Type DRUG

Other Intervention Names

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desflurane with remifetanil group Desflurane alone group

Eligibility Criteria

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Inclusion Criteria

* Age 20-60
* patients undergoing elective surgery take more than an hour
* Under general anesthesia using an LMA
* ASA I,II

Exclusion Criteria

* Patients on CNS depressants
* Chronic opioid use
* Corticosteroid
* Pregnant patients
* Full stomach
* Morbidly obese (BMI \>35kg/m2)
* Hepatitis B
* Hepatitis C
* Coronary artery disease
* Liver disease
* Renal disease
* Seizure disorder

Dropout criteria:

* Need for reintubation due to breath holding
* high ETCO2 during self ventilation (ETCO2\>50)
* Surgeon or patient request

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No