The EC50 of Remifentanil Blunting Hemodynamic Response to Double Lumen Tube Intubation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to evaluate the effect site concentration of remifentanil blunting hemodynamic changes to tracheal intubation of single or double lumen tubes.

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Detailed Description

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Conditions

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Hemodynamic Responses During Tracheal Intubation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Single lumen tube

Single lumen tube intubation during remifentanil infusion

Group Type ACTIVE_COMPARATOR

Remifentanil

Intervention Type DRUG

According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during single lumen tube intubation. For this allocation of dose of remifentanil the investigators use up-and-down method.

For the first patient, the dose of remifentanil would be fixed at 6.0 ng/ml which we predict as EC50. Step size of dose is 0.5ng/ml.

Double lumen tube

Double lumen tube intubation during remifentanil infusion

Group Type ACTIVE_COMPARATOR

Remifentanil

Intervention Type DRUG

According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during double lumen tube intubation. For this allocation of dose of remifentanil the investigators use up-and-down method.

For the first patient, the dose of remifentanil would be fixed at 6.0 ng/ml which we predict as EC50. And, step size of dose is 0.5ng/ml.

Interventions

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Remifentanil

According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during double lumen tube intubation. For this allocation of dose of remifentanil the investigators use up-and-down method.

For the first patient, the dose of remifentanil would be fixed at 6.0 ng/ml which we predict as EC50. And, step size of dose is 0.5ng/ml.

Intervention Type DRUG

Remifentanil

According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during single lumen tube intubation. For this allocation of dose of remifentanil the investigators use up-and-down method.

For the first patient, the dose of remifentanil would be fixed at 6.0 ng/ml which we predict as EC50. Step size of dose is 0.5ng/ml.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing thoracic surgery that require one lung ventilation

Exclusion Criteria

* patient who does not agree with this study
* BMI \< 16.0 or BMI \> 30
* cardiovascular disease, pulmonary disease, renal disease
* alcoholic abuser or drug abuser
* patient who takes any drug to influence cardiovascular system or sympathetic nervous system
* any use of local anesthetics or drugs to influence cardiovascular system during tracheal intubation

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No