Effects of Sufentanil on the Intraoperative Hemodynamics

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

92 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-24

Study Completion Date

2026-11-01

Brief Summary

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This study is a randomized, controlled trial. A total of 92 patients will be randomized to receive sufentanil or remifentanil during extracranial-intracranial bypass surgery.

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Detailed Description

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Conditions

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Intraoperative Hypotension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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sufentanil group

sufentanil is administered for analgesic during general anesthesia

Group Type EXPERIMENTAL

Sufentanil

Intervention Type DRUG

Induction: sufentanil TCI 0.3 ng/ml Maintenance: sufentanil TCI 0.05-0.5 ng/ml

remifentanil group

remifentanil is administered for analgesic during general anesthesia

Group Type ACTIVE_COMPARATOR

Remifentanil

Intervention Type DRUG

Induction: remifentanil TCI 3 ng/ml Maintenance: remifentanil TCI 0.5-5 ng/ml

Interventions

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Sufentanil

Induction: sufentanil TCI 0.3 ng/ml Maintenance: sufentanil TCI 0.05-0.5 ng/ml

Intervention Type DRUG

Remifentanil

Induction: remifentanil TCI 3 ng/ml Maintenance: remifentanil TCI 0.5-5 ng/ml

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who undergo elective extracranial-intracranial bypass surgery
* American Society of Anesthesiologists grade 1,2,3
* Age \> 18 years old

Exclusion Criteria

* Refuse to participate to the study
* American Society of Anesthesiologists grade 4
* Body Mass Index \< 18.5 kg/m2 or \> 35 kg/m2
* Allergic history of opioid
* pregnant
* MAO Inhibitor user
* Severe respiratory insufficiency

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No