Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Study Results

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Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2024-12-31

Brief Summary

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Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

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Detailed Description

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The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.

Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.

Conditions

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Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Desflurane

Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1\~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

Group Type ACTIVE_COMPARATOR

desflurane

Intervention Type DRUG

Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia.

Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.

Propofol

Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1\~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

Group Type ACTIVE_COMPARATOR

propofol

Intervention Type DRUG

Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.

Interventions

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desflurane

Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia.

Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.

Intervention Type DRUG

propofol

Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.

Intervention Type DRUG

Other Intervention Names

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Suprene Diprivan

Eligibility Criteria

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Inclusion Criteria

* Patients agree to participate in the study
* Patients undergoing lung cancer surgery requiring one-lung ventilation.
* American Society of Anesthesiologists Physical Status Class 1 or 2

Exclusion Criteria

* Patients with any of the following will be excluded from lung cancer patients.
* New York Heart Association Classification more than 2
* Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
* Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
* Coagulation dysfunction
* The administration of steroids and immunosuppressive agents within 3 months prior to surgery
* Infection with active inflammation
* Pneumonectomy patients
* Cases of epidural anesthesia is contraindicated

Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No