Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

NCT ID: NCT02394418

Last Updated: 2019-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Clinical Phase

PHASE4

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-01

Study Completion Date

2018-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Assessment of sedative effects of sevoflurane, dexmedetomidine and propofol on the clinical course of delirium, SIRS and neuroinflammation in mechanically ventilated patients using CAM-ICU scale, GSK-3beta and protein S100b in serum.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Delirium

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sevoflurane

Treatment of delirium by inhaled sevoflurane

Group Type ACTIVE_COMPARATOR

Sevoflurane

Intervention Type DRUG

Treatment of delirium by inhaled sevoflurane

Propofol

Treatment of delirium by propofol i.v. infusion

Group Type ACTIVE_COMPARATOR

Propofol

Intervention Type DRUG

Treatment of delirium by propofol i.v. infusion

Dexmedetomidine

Treatment of delirium by dexmedetomidine i.v. infusion

Group Type ACTIVE_COMPARATOR

Dexmedetomidine

Intervention Type DRUG

Treatment of delirium by dexmedetomidine i.v. infusion

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Sevoflurane

Treatment of delirium by inhaled sevoflurane

Intervention Type DRUG

Propofol

Treatment of delirium by propofol i.v. infusion

Intervention Type DRUG

Dexmedetomidine

Treatment of delirium by dexmedetomidine i.v. infusion

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Sevorane Diprivan Dexdor

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* presence of delirium

Exclusion Criteria

* presence of Alzheimer's disease
* any mental disorder
* presence of cancer
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Moscow Regional Research and Clinical Institute (MONIKI)

OTHER_GOV

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Valery V. Likhvantsev, Professor

senior researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Valery Likhvantsev, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Moscow Regional Research Clinical Institute

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

S-D-P-MV-220115

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Ketamine Versus Propofol as ICU Sedation
NCT06243822 COMPLETED PHASE4
SEvoflurane for Sedation in ARds
NCT04235608 COMPLETED PHASE3