Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
NCT ID: NCT06788743
Last Updated: 2026-01-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
450 participants
INTERVENTIONAL
2025-06-01
2026-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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TIVA
Participants assigned to the TIVA group will receive propofol combined with remifentanil for anesthesia maintenance during the surgery
TIVA ( anesthesia with propofol and remifentanil)
Participants assigned to the TIVA group will receive propofol combined with remifentanil for anesthesia maintenance during the surgery
VA
Participants assigned to the VA group will receive sevoflurane combined with remifentanil for anesthesia maintenance during the surgery.
VA（anesthesia with sevoflurane and remifentanil）
Participants assigned to the VA group will receive sevoflurane combined with remifentanil for anesthesia maintenance during the surgery.
Interventions
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TIVA ( anesthesia with propofol and remifentanil)
Participants assigned to the TIVA group will receive propofol combined with remifentanil for anesthesia maintenance during the surgery
VA（anesthesia with sevoflurane and remifentanil）
Participants assigned to the VA group will receive sevoflurane combined with remifentanil for anesthesia maintenance during the surgery.
Eligibility Criteria
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Inclusion Criteria
* Elective surgery (with an expected duration of 2 hours or more)
* ASA grade Ⅰ-Ⅲ
* Voluntary participation and informed consent obtained
* Diabetes mellitus
Exclusion Criteria
* Severe visual or auditory impairments, language barriers, or patients who cannot cooperate
* Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse
* Neurosurgical patients
* Patients who are expected to require hepatic portal blockage during surgery
* Patients who are expected to be transferred to ICU after surgery
* Patients with a known allergy to the drugs used in this study or those suspected of having propofol infusion syndrome
60 Years
ALL
No
Sponsors
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Xijing Hospital
OTHER
Responsible Party
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Locations
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The First Affiliated Hospital of Air Force Medical University
Xi’an, Shanxi, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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NCT06788743
Identifier Type: -
Identifier Source: org_study_id
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