POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

110 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Study Completion Date

2014-08-31

Brief Summary

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The use of desflurane in elderly subjects (\>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

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Detailed Description

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Conditions

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1. Postoperative Cognitive Dysfunction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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desflurane and sevoflurane

Subjects will be randomized to either desflurane or sevoflurane. They will be given the Mini Mental State exam at 1, 6 and 24 hours after the end of anesthesia.

The intervention will be Mini-Mental Status Examination (MMSE)

Intervention Type OTHER

A questionnaire given to the study patient before and after the anesthetic at 1, 6 and 24 hours.

Interventions

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The intervention will be Mini-Mental Status Examination (MMSE)

A questionnaire given to the study patient before and after the anesthetic at 1, 6 and 24 hours.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult patients (\>65 years old)
* Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
* Airway management expected to include endotracheal intubation
* Expected surgical duration 120 to 240 minutes

Exclusion Criteria

* Pre-existing significant psychiatric disease or mental status changes
* Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease
* Patient's weighing \>50% ideal body weight

* Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
* Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet
* Patients who have undergone a general anesthetic within the past 7 days
* Patient refusal

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No