Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

NCT ID: NCT01379664

Last Updated: 2017-04-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 1584 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-07-31
• Study Completion Date: 2013-04-30

Brief Summary

Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane.

The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.

Conditions

Duration of Hospitalization

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

Isoflurane

Isoflurane is to be administered to patients in this arm during surgery

Group Type: EXPERIMENTAL

Isoflurane

Intervention Type: DRUG

Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Sevoflurane

Sevoflurane is to be administered to patients in this arm during surgery

Group Type: EXPERIMENTAL

Sevoflurane

Intervention Type: DRUG

Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Interventions

Isoflurane

Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Intervention Type: DRUG

Sevoflurane

Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Must have surgery in G operating room suite

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Cleveland Clinic

OTHER

Sponsor Role: lead

Responsible Party

d sessler

Professor & Chair

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Daniel I Sessler, MD

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Locations

Cleveland Clinic

Cleveland, Ohio, United States

Countries

United States

Other Identifiers

11-440

Identifier Type: -

Identifier Source: org_study_id