The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

NCT ID: NCT01267786

Last Updated: 2010-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Brief Summary

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The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Detailed Description

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Conditions

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Apoptosis Liver Surgery

Keywords

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Oxidotic stress

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Sevoflurane

1MAC intraoperatively

Group Type ACTIVE_COMPARATOR

Liver surgery

Intervention Type PROCEDURE

hepatectomy

desflurane

1 MAC intraoperatively

Group Type ACTIVE_COMPARATOR

Liver surgery

Intervention Type PROCEDURE

hepatectomy

Interventions

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Liver surgery

hepatectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing liver surgery

Exclusion Criteria

* ASA IV, Cardiovascular diseases
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aretaieio Hospital

OTHER

Sponsor Role lead

Responsible Party

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University of Athens

Principal Investigators

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Georgios P Fragulidis, MD

Role: PRINCIPAL_INVESTIGATOR

Areataieio Hospital

Locations

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Aretaieio Hospital

Athens, Attica, Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Georgios P Fragulidis, MD

Role: CONTACT

Phone: +30 6072910955

Email: [email protected]

Aikaterini D Melemeni, MD, DESA

Role: CONTACT

Phone: +30 6946194817

Email: [email protected]

Other Identifiers

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AnesthSurg1

Identifier Type: -

Identifier Source: org_study_id