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Anesthesia and Acute Kidney Injury After Nephrectomy

NCT ID: NCT04474600

Last Updated: 2024-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

324 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-07-20

Study Completion Date

2024-03-06

Brief Summary

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This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.

Detailed Description

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Nephrectomy is considered as a standard therapy for renal cell carcinoma, but it can cause postoperative renal dysfunction, such as acute kidney injury and chronic kidney disease. Therefore, it is imperative to identify modifiable risk factors for postoperative acute kidney injury after nephrectomy in advance. According to a recent retrospective study, total intravenous anesthesia using propofol is significantly associated with lower incidence of acute kidney injury after nephrectomy, compared to the inhalation anesthesia. However, there is no prospective study which investigates the influence of type of anesthesia on postoperative renal function after nephrectomy. Therefore, in the present study, we aimed to investigate the influence of type of anesthesia on acute kidney injury after nephrectomy by performing randomized controlled study.

Conditions

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Nephrectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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TIVA group

Patients receiving the total intravenous anesthesia using propofol

Group Type EXPERIMENTAL

Propofol

Intervention Type DRUG

The induction and maintenance of anesthesia was performed by total intravenous anesthesia using propofol. In both groups, remifentanil is continuously infused throughout the surgery.

Inhalation group

Patients receiving inhalation anesthesia using desflurane

Group Type ACTIVE_COMPARATOR

Desflurane

Intervention Type DRUG

The induction and maintenance of anesthesia was performed by inhalation anesthesia using desflurane. In both groups, remifentanil is continuously infused throughout the surgery.

Interventions

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Propofol

The induction and maintenance of anesthesia was performed by total intravenous anesthesia using propofol. In both groups, remifentanil is continuously infused throughout the surgery.

Intervention Type DRUG

Desflurane

The induction and maintenance of anesthesia was performed by inhalation anesthesia using desflurane. In both groups, remifentanil is continuously infused throughout the surgery.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adults patients scheduled for elective open nephrectomy

Exclusion Criteria

* Patients diagnosed with acute kidney injury preoperatively
* Patients who have chronic kidney disease over stage 5 (estimated glomerular filtration rate \[eGFR\] \<15 ml/kg/1.73m2) or have regular hemodialysis preoperatively
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hyun-Kyu Yoon

clinical assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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Anesthetics_Nx_AKI

Identifier Type: -

Identifier Source: org_study_id