Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
NCT ID: NCT02932865
Last Updated: 2023-11-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
120 participants
OBSERVATIONAL
2016-11-30
2023-11-30
Brief Summary
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Detailed Description
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Seminal plasma and serum samples are collected and miRNA and piRNA are analyzed. Steroid hormones are analyzed by liquid chromatography-tandem mass spectrometry. The participants are given a physical examination and testicular ultrasound. The primary aim of this study is to develop a tool to better estimate the sperm recovery rate (SRR) of azoospermic men scheduled for MD-TESE. Since no data have been published presenting miRNA and piRNA levels in men with normal semen, a secondary aim is to describe the levels of miRNA and piRNA in unselected men. Third part of this study aims to find if medical treatment improving semen parameters affects miRNA ja piRNA findings.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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MD-TESE (A)
Azoospermic men, MD-TESE operation (standard treatment). Semen sample, serum sample and physical examination with testicular ultrasound.
No interventions assigned to this group
Subfertile men (B)
Subfertile men receiving medication (standard treatment). Semen sample, serum sample and physical examination with testicular ultrasound.
No interventions assigned to this group
Control (C)
Control group, men scheduled for semen analysis. Semen sample, serum sample and physical examination with testicular ultrasound.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Inadequate language skills for informed consent
18 Years
60 Years
MALE
Yes
Sponsors
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Lund University Hospital
OTHER
University of Turku
OTHER
Turku University Hospital
OTHER_GOV
Responsible Party
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Principal Investigators
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Antti Perheentupa, MD,PhD
Role: STUDY_DIRECTOR
University of Turku
Locations
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Turku University Hospital
Turku, , Finland
Countries
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Other Identifiers
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SemiFluid
Identifier Type: -
Identifier Source: org_study_id
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