Treatment of Severe Male Infertility - Predictive Factors (Imaging)

NCT ID: NCT02931721

Last Updated: 2023-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-01

Study Completion Date

2023-07-31

Brief Summary

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Testes of men with non-obstructive azoospermia (NOA) are imaged using MRI to find potential differences depending on the outcome, ie. sperm recovery in consequent microdissection testicular sperm extraction (MD-TESE).

Detailed Description

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Sperm recovery rate in non-obstructive azoospermia (NOA) men is 43% in Turku University Hospital, depending on the diagnosis leading to NOA. To date, there are no known parameters known to differentiate between successful and unsuccessful sperm recovery.

MRI is performed on men prior to the operation, and the objective is to compare the functional parameters assessed by magnetic resonance imaging between the group of men with positive and the men with negative sperm recovery in testicular microdissection sperm extraction (MD-TESE).

Conditions

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Male Infertility

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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MRI Positive

Men with sperm found in MD-TESE

MRI

Intervention Type DIAGNOSTIC_TEST

Pelvis MRI

MRI Negative

Men with no sperm found in MD-TESE

MRI

Intervention Type DIAGNOSTIC_TEST

Pelvis MRI

Control group

No intervention, fertile

MRI

Intervention Type DIAGNOSTIC_TEST

Pelvis MRI

Interventions

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MRI

Pelvis MRI

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* non obstructive azospermia

Exclusion Criteria

* malignancy
* contraindication for fertility treatment
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Turku University Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Rauni Klami

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Antti Perheentupa, MD,PhD

Role: STUDY_DIRECTOR

Turku University Hospital

Locations

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Turku University Hospital, Dept of Obst and Gyn

Turku, , Finland

Site Status

Dept of Obst and Gyn

Turku, , Finland

Site Status

Countries

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Finland

Other Identifiers

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TESE-MRI

Identifier Type: -

Identifier Source: org_study_id

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