Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
NCT ID: NCT03180918
Last Updated: 2022-11-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2015-01-31
2100-01-31
Brief Summary
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Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, sperm cryopreservation should be offered to all pubertal male patients. For prepubertal boys, only the experimental option of testicular biopsy in order to cryopreserve testicular stem cells can be proposed.
Primary aims
\- To cryopreserve testicular tissue of prepubertal patient receiving highly gonadotoxic oncological treatment.
Secondary aims
* To cryopreserve testicular tissue after failure of sperm cryopreservation in pubertal patient with high risk of infertility
* To create a database in order to record clinical and biological follow-up data
* To create a research biobank for future research projects
Multicentric study: HUG, CHUV, UKBB
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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testicular tissue cryopreservation
testicular tissue biopsy
testicular tissue biopsy during general anesthesia
Interventions
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testicular tissue biopsy
testicular tissue biopsy during general anesthesia
Eligibility Criteria
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Inclusion Criteria
* Peri and pubertal patients after failure of sperm cryopreservation
* Patients presenting high risk of infertility because of gonadotoxic treatments (i.e high dose of alkylating agents, testicular irradiation, total body irradiation).
* Multidisciplinary team consensus in favour of proposition to cryopreserve testicular tissue
Exclusion Criteria
* Refusal of the patient and/or his parents
* Treatments that are not highly gonadotoxic
3 Months
18 Years
MALE
No
Sponsors
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Gumy-Pause Fabienne
OTHER
Responsible Party
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Gumy-Pause Fabienne
Principal Investigator
Principal Investigators
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Fabienne Gumy-Pause
Role: STUDY_CHAIR
University Hospital, Geneva
Locations
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UKBB
Basel, , Switzerland
Geneva University Hospitals
Geneva, , Switzerland
CHUV
Lausanne, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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Tamara Diesch-Furlanetto, Dr
Role: primary
Maja Beck Popovic, Dr
Role: primary
Other Identifiers
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PB_2016-01378
Identifier Type: -
Identifier Source: org_study_id
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