Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

NCT ID: NCT06587477

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-16

Study Completion Date

2028-06-30

Brief Summary

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Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.

Detailed Description

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This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old, currently \> 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.

Conditions

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Cancer, Treatment-Related Late Effect Semen Analysis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Male childhood and adolescent cancer survivors

Male childhood and adolescent cancer survivors

Hormonal profile

Intervention Type OTHER

Blood for FSH, LH, testosterone

Semen analysis

Intervention Type OTHER

Semen analysis

Questionnaire

Intervention Type OTHER

The European Male Ageing Study (EMAS) questionnaire

Controls

Aged-matched controls from men attending the Family Planning Association for premarital check-up

Hormonal profile

Intervention Type OTHER

Blood for FSH, LH, testosterone

Semen analysis

Intervention Type OTHER

Semen analysis

Questionnaire

Intervention Type OTHER

The European Male Ageing Study (EMAS) questionnaire

Interventions

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Hormonal profile

Blood for FSH, LH, testosterone

Intervention Type OTHER

Semen analysis

Semen analysis

Intervention Type OTHER

Questionnaire

The European Male Ageing Study (EMAS) questionnaire

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old.
* \> 18 years old to 50 years old
* Cancer in remission for at least 2 years

Exclusion Criteria

* Unable to ejaculate by masturbation to provide semen samples
* Cryptorchidism, testicular cancer, history of vasectomy
* On testosterone replacement therapy
* Refusal to join the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Queen Mary Hospital, Hong Kong

OTHER

Sponsor Role collaborator

Prince of Wales Hospital, Shatin, Hong Kong

OTHER

Sponsor Role collaborator

Hong Kong Children's Hospital

OTHER

Sponsor Role collaborator

The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Queen Mary Hospital

Hong Kong, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jennifer Ko

Role: CONTACT

Facility Contacts

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Jennifer Ko

Role: primary

Other Identifiers

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UW21-038

Identifier Type: -

Identifier Source: org_study_id

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