A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12215 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2018-01-03

Brief Summary

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The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total progressive sperm number of 2 x 10\^6 after pretreatment as the boundary value, and will divide total progressive sperm number of 2 x 10\^6 after pretreatment into 2 x 10\^6 or higher and \< 2 x 10\^6 groups, and will further divide \< 2 x 10\^6 group into: = 0, (0,10\^6\], (10\^6, 2 x 10\^6) three groups. Propensity score matching will be used to balance the baseline data between four groups. The matching variables are age, female BMI, AFC, AMH and ICSI.

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Detailed Description

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Conditions

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Sperm Count, Low Reproductive Sterility

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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group1

A+B grade sperm count after treatment=0

semen pretreatment

Intervention Type OTHER

semen pretreatment

group2

0\<A+B grade sperm count after treatment≤10\^6

semen pretreatment

Intervention Type OTHER

semen pretreatment

group3

10\^6\<A+B grade sperm count after treatment\<2\*10\^6

semen pretreatment

Intervention Type OTHER

semen pretreatment

group4

A+B grade sperm count after treatment≥2\*10\^6

semen pretreatment

Intervention Type OTHER

semen pretreatment

Interventions

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semen pretreatment

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* infertility female and sterility male for reproductive treatment

Exclusion Criteria

* chromosomal abnormalities
* none retrieval oocyte
* none oocyte for ICSI
* Recurrent abortion
* female age≥37 years
* Assisted hatching
* abnormal oocyte zona pellucida
* In Vitro Maturation
* AZF microdeletion

Eligible Sex

ALL

Accepts Healthy Volunteers

No