IMSI in Couples With Previous Implantation Failures

NCT ID: NCT02107521

Last Updated: 2014-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Brief Summary

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There is a lack of clarity regarding the justification to instruct the couple to shift from intracytoplasmic sperm injection (ICSI) to intracytoplasmic morphologically selected sperm injection (IMSI). In this study, we aim at evaluating the efficacy of IMSI in couples with previous implantation failure with ICSI.

Detailed Description

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Conditions

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Male Infertility Female Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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ICSI group

In this group, sperm selected for injection will be morphologically evaluated under 400x magnification

Group Type ACTIVE_COMPARATOR

Intracytoplasmic sperm injection

Intervention Type OTHER

sperm selection for injection will be performed under 400x magnification

IMSI group

In this group, sperm selected for injection will be morphologically evaluated under 6600x magnification

Group Type EXPERIMENTAL

Intracytoplasmic morphologically selected sperm injection

Intervention Type OTHER

Sperm selection for injection will be performed at 6600x magnification

Interventions

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Intracytoplasmic morphologically selected sperm injection

Sperm selection for injection will be performed at 6600x magnification

Intervention Type OTHER

Intracytoplasmic sperm injection

sperm selection for injection will be performed under 400x magnification

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with ICSI indication, who have previously underwent \>= 1 ICSI attempt in which at least 2 blastocysts were transferred, with no implantation.
* Regular menstrual cycles every 25-35 days.
* Body Mass Index less than 35 as calculated according to the following formula: body weight (kg) / height x height (m2)
* Presence of both ovaries.
* No pelvic and / or clinically significant uterine anomalies.
* Normal cervical cytology.
* Serum follicle stimulating hormone (FSH) within normal limits.

Exclusion Criteria

* Clinically significant systemic disease.
* Infection by the human immunodeficiency virus (HIV).
* Infection by the by the hepatitis C virus
* Positive test for surface antigens of hepatitis B.
* Endometriosis stages III - IV (classification of the American Society for Reproductive Medicine).
* Hydrosalpinx, unilateral or bilateral.
* Abnormal gynecological bleeding, undiagnosed.
* Allergy or hypersensitivity to human gonadotropin preparations or any other related to the study medication.

-Simultaneous participation in another clinical trial. -
Maximum Eligible Age

38 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Sapientiae Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Edson Borges, PhD

Role: PRINCIPAL_INVESTIGATOR

Sapientiae Institute

Locations

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Fertility - Centro de Fertilização Assistida

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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Sapi IMSI IF

Identifier Type: -

Identifier Source: org_study_id