Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2016-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Antioxidant group
In the control group, all patients will go a double-blind therapy of a three-months period of treatment with oral carnitine (2g daily). After this period, all patients will undergo conventional intacytoplasmic sperm injection (ICSI).
No interventions assigned to this group
Antioxidant+modifiable lifestyle factors
In the study group, all patients underwent a double-blind therapy of a six-month period of treatment with oral carnitine (2g daily) combined with modifiable lifestyle factors. Patients were requested to follow a healthy standard diet, avoid excessive heat exposure, avoid or minimize exposure to pollutants, and stop smoking, coffee, alcohol, and drugs uptake.After this period, all patients will undergo conventional ICSI.
Antioxidant (l-cratinine) + modifiable lifestyle factors
All participants were subjected to the same three-month period treatment protocol, which included 1) antioxidant treatment with L-Carnitine (2g daily); 2) frequent ejaculation every 2 days; and 3) minimizing adverse lifestyle factors.
Interventions
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Antioxidant (l-cratinine) + modifiable lifestyle factors
All participants were subjected to the same three-month period treatment protocol, which included 1) antioxidant treatment with L-Carnitine (2g daily); 2) frequent ejaculation every 2 days; and 3) minimizing adverse lifestyle factors.
Eligibility Criteria
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Inclusion Criteria
* Oligoasthenoteratozoospermic male partner ( (count \< 0.5 million/ml, Motility=\< 40% Progressive motility =\<10 %, Abnormal forms \>99%).
* Fresh semen samples.
Exclusion Criteria
* Incomplete ICSI cycles
* Endometrial thickness\> 7mm
20 Years
39 Years
FEMALE
No
Sponsors
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Benha University
OTHER
Responsible Party
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Salah Elbashir
Assisting lecturer of Urology
Principal Investigators
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Salah Elbashir
Role: STUDY_DIRECTOR
Department of Urology, Benha university, Egypt
Locations
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Dar Almaraa fertility and gynacology center
Cairo, , Egypt
Elite fertility care center
Cairo, , Egypt
Nile badrawi Hospital
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Yasmin Magdi, M.Sc
Role: primary
Prof. Ayman Rashed, pHD
Role: primary
Ahmed El-Damen, M.Sc
Role: primary
References
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Tremellen K, Miari G, Froiland D, Thompson J. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Aust N Z J Obstet Gynaecol. 2007 Jun;47(3):216-21. doi: 10.1111/j.1479-828X.2007.00723.x.
Other Identifiers
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00287597
Identifier Type: -
Identifier Source: org_study_id
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