Identifying Candidates for Limited Dissection at Microdissection TESE.

NCT ID: NCT07286279

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-12-15

Study Completion Date

2026-01-15

Brief Summary

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The goal of this retrospective observational study is to learn whether certain clinical characteristics can help predict which infertile men may successfully have sperm retrieved using a less-invasive "mini-incision" version of micro-TESE. The study focuses on men with very low or absent sperm counts (non-obstructive azoospermia, cryptozoospermia, or severe OAT).

The main questions it aims to answer are:

Can sperm be successfully found using only a small, limited-dissection micro-TESE in some men?

Which clinical factors (such as hormone levels or medical history) help identify men who may benefit from this less-invasive approach?

Researchers will compare men who had successful sperm retrieval with the mini-incision alone to men who required a more extensive micro-TESE to see if certain characteristics predict which approach is likely to work.

Detailed Description

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This retrospective cohort study evaluates whether preoperative clinical characteristics can help identify infertile men who are likely to achieve successful sperm retrieval through a limited-dissection, mini-incision micro-TESE. The stepwise surgical approach begins with a small equatorial incision for targeted micro-biopsies and is expanded only when sperm are not initially identified.

The study includes men who underwent their first micro-TESE at a high-volume fertility center over a 10-year period. All procedures followed a standardized surgical protocol and were performed by a single experienced surgeon, ensuring uniformity in technique.

Clinical data routinely collected before surgery, such as hormone levels, semen parameters, testicular volume, and relevant medical history, were analyzed and compared between men who required only the mini-incision and those who proceeded to an extended dissection. By examining these differences, the study aims to determine whether certain patient characteristics can predict the success with the less-invasive approach.

The findings may help guide pre-surgical counseling and support more tailored surgical planning for men with severe male factor infertility

Conditions

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Non Obstructive Azoospermia Cryptozoospermia Oligoasthenoteratozoospermia Male Infertility

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients with cryptozoospermia or non obstructive azoospermia that underwent a micro-TESE

Exclusion Criteria

* Patients with a potentially reversible cause of cryptozoospermia (i.e., presence of a varicocele, febrile illness, or recent toxin exposure)
* Patients with suspected partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)
* Patients who have previously undergone a micro-TESE, TESA or TESE procedure
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Clinique Ovo

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Clinique ovo

Montreal, Quebec, Canada

Site Status

Countries

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Canada

Central Contacts

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Marya Far, M.Sc

Role: CONTACT

514-798-2000 ext. 759

Marion Vivien, PhD

Role: CONTACT

514-798-2000 ext. 627

Facility Contacts

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Marya Far, M.Sc

Role: primary

5147982000 ext. 759

Marion Vivien, PhD

Role: backup

514-798-2000 ext. 627

Other Identifiers

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Mini incision Micro-TESE

Identifier Type: -

Identifier Source: org_study_id