Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2014-06-30

Brief Summary

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Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive azoospermia may be a predictive test before surgical testicular biopsy to determine the chance of a positive sperm extraction to use for ICSI.

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Detailed Description

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The aim of this study is to compare the levels of esttradiol and testosterone in seminal plasma of men with non-obstructive azoospermia. Indeed, for these patients, none biological test allows to predict a positive sperm extraction before the surgical testis biopsy is performed. Since the involvement of estradiol and testosterone in the regulation of spermatogenesis, the measurement of these hormones in seminal plasma may be a predictive tool for these men before testis biopsy.

Conditions

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Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Interventions

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ESTRADIOL

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Azoospermia confirmed by two semen analysis (at minimum 74 days between the both analysis)
* Volume of seminal plasma \>0.6ml
* Testicular biopsy one month after the last semen analysis
* Informed consent signed by the patient