Seminal Level of Clusterin Before Testicular Sperm Extraction
NCT ID: NCT03857828
Last Updated: 2020-12-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
88 participants
OBSERVATIONAL
2020-12-16
2021-05-01
Brief Summary
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Detailed Description
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It plays important roles in several pathophysiological processes, including tissue remodelling, lipid transport, reproduction, complement regulation and apoptotic cell death .
As clusterin expression is markedly upregulated in various normal and malignant tissues undergoing apoptosis, it has been regarded as a marker for cell death.
There is a conflicting findings concerning the relationship between elevated clusterin expression and enhanced induction of apoptosis; that is, clusterin has appeared to have a powerful anti-apoptotic function through a chaperone-like activity.
In addition to the anti-apoptotic activity, seminal clusterin was reported to promote a tolerogenic response to male antigens, thereby contributing to female tolerance to seminal antigens.
In the testis, clusterin is secreted by Sertoli cells into the fluid of the seminiferous epithelium and deposited onto the membranes of elongating spermatids and mature spermatozoa.
To date, however, there has been little information with respect to the functional roles of clusterin in the male reproductive tract under physiological conditions.
In particular, it remains controversial as to whether or not clusterin helps assist the normal spermatogenesis.
Nonobstructive azoospermia (NOA) males are characterised by impaired spermatogenesis.
Although NOA patients have impaired global spermatogenic function, focal areas of spermatogenesis may still exist in their testes.
Focal spermatogenesis could possibly be obtained by testicular sperm extraction (TESE) technique .
A number of factors have been suggested to be of predictive value for patients with a good chance to retrieve sperm cell such as testicular volume, serum FSH levels , serum total testosterone and serum inhibin B levels.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Interventions
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semen sample
• seminal sample for measuring clusterin level.
Eligibility Criteria
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Inclusion Criteria
* Age: 20-50 year
Exclusion Criteria
* Cryptorchidism .
* Testicular Agenesis and testicular atrophy .
20 Years
50 Years
MALE
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Azza Sheshaey Hassan Abdelfadel Ahmad
Principal investigator
Central Contacts
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Emad Eldien Kamal, Ph.D
Role: CONTACT
Phone: 01004026100
Other Identifiers
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CLu before TESE
Identifier Type: -
Identifier Source: org_study_id