Epididymal U.S Findings in Asthenozoospermic &Correlation With L.Carnitine Level

NCT ID: NCT05436080

Last Updated: 2023-08-16

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-08-01
• Study Completion Date: 2024-12-31

Brief Summary

To evaluate the epididymal findings by U.S and study its correlation with seminal parameters including L.carnitine level in infertile males

Detailed Description

infertility is a relatively common problem affecting about15-20% of reproductive aged couples. Historically, the cause of infertility was falsified attributed to the female partner, while the male factor, which is either primary or a co factor in 40-60% of cases, has largely been ignored Thus, it is important to evaluate men at the same time with women.(2) The epididymis is an elongated structure, posterolateral to the testis within the scrotal sac. Its primary function is the collection, maturation and transport of sperm from rete testis to the ductus deferens.(1)(3) Testicular spermatozoa are nonfunctional and lack the ability to naturally fertilize an oocyte .After, spermatozoa reach the epididymis they undergo a complicated maturation process leading to biochemical, physiological and functional changes resulting in a functional spermatozo on that is able to successfully fertilize an oocyte (3)(4)(8) Sperm dysfunctions are recognised as the most significant cause of male infertility and many may think that sperm dysfunction is only as a result of defective spermatogenesis. However, it can also be the result of an inadequate epididymal maturation process due to improper epididymal function (6)(7)(8) Scrotal sonography is commonly used for evaluation of the infertile male. While abnormalities of the epididymis like( cysts and calcifications ) are frequently observed during sonographic assessment and their presence has uncertain importance (1)(10)(12)(13) Measurement of acetyl carnitine content of human seminal plasma could be used as a marker of epididymal maturation. Carnitine is present in the epididymis at higher concentrations than in other body tissues in the rat

Conditions

Asthenozoospermia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

U/S

Epididymal Ultrasongraphic Findings by Scrotal U/S

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• 80 married male( 50 asthenzoospermic infertile male and 30 with normal semen male) Age from 18 to 55 years.

Exclusion Criteria

• Extreme age
• Single
• Recent L carnitine intake
• Undesended testis
• Genetic cause of inferitility
• Patients with clinical Varicocele
• Azoospermic patients

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Yasser Mohamed Abo Elyamen

Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Emad abdel rahiem taha

Role: STUDY_DIRECTOR

Assiut University

Ahmed mahmoud el shibany

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

yasser mohamed

Role: CONTACT

taher2014mohamed@yahoo.com

01555509202

References

Lotti F, Frizza F, Balercia G, Barbonetti A, Behre HM, Calogero AE, Cremers JF, Francavilla F, Isidori AM, Kliesch S, La Vignera S, Lenzi A, Marcou M, Pilatz A, Poolamets O, Punab M, Peraza Godoy MF, Rajmil O, Salvio G, Shaeer O, Weidner W, Maseroli E, Cipriani S, Baldi E, Degl'Innocenti S, Danza G, Caldini AL, Terreni A, Boni L, Krausz C, Maggi M. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Scrotal ultrasound reference ranges and associations with clinical, seminal, and biochemical characteristics. Andrology. 2021 Mar;9(2):559-576. doi: 10.1111/andr.12951. Epub 2021 Jan 19.

Reference Type: BACKGROUND

PMID: 33244893 (View on PubMed)

Other Identifiers

epididymal findindgs by u.s

Identifier Type: -

Identifier Source: org_study_id