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Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)

NCT ID: NCT00484081

Last Updated: 2007-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

53 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2006-10-31

Brief Summary

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We evaluated the application of surgical testicular exploration with the aid of a microscope (MictoTESE) to increase the chances of obtaining sperm in men with impaired sperm production, a condition known as non-obstructive azoospermia.

We also evaluated the outcomes of these couples when the sperm obtained were used in ICSI (Intracytoplasmic Sperm Injection) during assisted reproductive technology treatment.

We believe that excellent results may be obtained with the use of the following techniques in the treatment of couples where non-obstructive azoospermia is a significant cause.

Detailed Description

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Men diagnosed with non-obstructive azoospermia and seeking assisted reproductive technology treatment (ART) are candidates for surgical sperm retrieval with the aid of microdissection. We believe that this approach may currently be the best option for these subjects.

We evaluated our surgical sperm retrieval rate associated to their serum LH, FSH, TOTAL TESTOTERONE and PROLACTIN levels, pre-operative testicular volume and also compared to the post-operative histological analysis of fixed testicular tissue specimens collected during the procedure, stained with haematoxylin and eosin.

We also evaluated the outcomes using ICSI based ART for these couples observing mean ICSI and fertilized oocytes, number and quality of embryos transferred, implantation and pregnancy rates.

Conditions

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Azoospermia Infertility

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Microdissection Testicular Sperm Extraction

Intervention Type PROCEDURE

ICSI

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Men undergoing ART treatment with clinical diagnosis of non-obstructive azoospermia.
* Female partner undergoing ICSI based ART treatment

Exclusion Criteria

* Men where non-obstructive azoospermia was not confirmed based on histological analysis of fixed testicular tissue specimens collected by open surgical testicular biopsy and stained with haematoxylin and eosin.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Clinic and Research Center in Human Reproduction Roger Abdelmassih

OTHER

Sponsor Role lead

Principal Investigators

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Pedro Ravizzini, Dr.

Role: PRINCIPAL_INVESTIGATOR

Clinic and Research Center in Human Reproduction Roger Abdelmassih

Locations

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Clinic and Research Center in Human Reproduction Roger Abdelmassih

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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RA9969

Identifier Type: -

Identifier Source: org_study_id