Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
45 participants
OBSERVATIONAL
2016-06-01
2026-05-31
Brief Summary
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Detailed Description
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Furthermore, the study aims to assess if the blood and seminal alterations of infertile patients have similarities with the same fluids of elderly patients, validating from a metabolomic and microbiomic point of view the hypothesis of premature aging of infertile patients.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Infertile men
Patients diagnosed with idiopathic non-obstructive azoospermia
Analysis of microbiome and metabolomics
Analysis of microbiome and metabolomics through the assessment of blood and semen parameters
Fertile men
fertile subjects (pregnancy within 12 months of the start of the research by the couple, according to WHO 2010 criteria)
Analysis of microbiome and metabolomics
Analysis of microbiome and metabolomics through the assessment of blood and semen parameters
Old fertile men
Subjects known to have been fertile subjects (pregnancy within 12 months of the start of the research by the couple, according to WHO 2010 criteria)
Analysis of microbiome and metabolomics
Analysis of microbiome and metabolomics through the assessment of blood and semen parameters
Interventions
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Analysis of microbiome and metabolomics
Analysis of microbiome and metabolomics through the assessment of blood and semen parameters
Eligibility Criteria
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Inclusion Criteria
* fertile men (pregnancy within 12 months from the start of the couple's search)
* men known to have been fertile aged between 65 and 75 (pregnancy within 12 months of the couple starting searching)
Exclusion Criteria
* endocrine alterations
* chromosomal alterations
* known genetic alterations
18 Years
75 Years
MALE
No
Sponsors
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IRCCS San Raffaele
OTHER
Responsible Party
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Andrea Salonia
Professor
Locations
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IRCCS Ospedale San Raffaele
Milan, Lombardy, Italy
Countries
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Central Contacts
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Facility Contacts
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Alessia d'Arma, PhD
Role: primary
Other Identifiers
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Metabolomicsµbiome
Identifier Type: -
Identifier Source: org_study_id