The Effects of Diet on Small Non-coding RNA I Sperm Cells and the Possible Effects on Reproductive Success: Diet Intervention Effects on Sperm
NCT ID: NCT06831292
Last Updated: 2025-02-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2024-12-26
2027-12-31
Brief Summary
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Detailed Description
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The intervention group will receive groceries with planned recipes during the hormonal treatment period for the woman (11-14 days) before IVF. The meal plan will be according to the Nordic dietary guidelines and individualized to match total energy expenditure.
The male partner must accept to participate in the diet intervention in order to be included and the female partner can choose to participate in the diet intervention but it is optional. Sperm samples will be collected before the start of hormonal treatment and on ovum pick-up day. Weight will be measured before and after the intervention. Sperm samples will be processed as standard practice at the fertility clinic. Sperm samples will be used for molecular analysis, such as small RNA sequencing.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Diet intervention- Nordic nutrition recommendations
The intervention group will receive groceries with planned recipes during the hormonal treatment period for the woman (11-14 days) before IVF. The meal plan will be according to the Nordic dietary guidelines and individualized to match total energy expenditure.
Diet intervention NMR
Participants will receive groceries to their homes with planned recipes. The recipes are planned by using the Nordic nutrition councils recommendations.
No diet intervention
No intervention - this group will only receive standard care
No interventions assigned to this group
Interventions
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Diet intervention NMR
Participants will receive groceries to their homes with planned recipes. The recipes are planned by using the Nordic nutrition councils recommendations.
Eligibility Criteria
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Inclusion Criteria
* Mature sperm cells in semen
* Able to speak and read Swedish
* Omnivore
* Will refrain from nicotine and alcohol during intervention
* Sperm sampled provided no more than 3 weeks before intervention start
Exclusion Criteria
* Former radiotherapy in pelvic area
* Former chemotherapy
* Known genetic/chromosomal disorder
* Food allergy
23 Years
56 Years
MALE
No
Sponsors
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Ostergotland County Council, Sweden
OTHER
Responsible Party
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Susanne Liffner
Principal Investigator
Locations
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University Hospital
Linköping, Östergötland County, Sweden
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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RÖ-961659 substudy 3
Identifier Type: -
Identifier Source: org_study_id
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