Is Oxidative Stress in Semen Reduced by Lifestyle Intervention
NCT ID: NCT03898752
Last Updated: 2021-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
31 participants
INTERVENTIONAL
2018-11-01
2020-11-01
Brief Summary
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It is hypothesized that men who also have a OS above 1.34 using a novel OS diagnostic method (MiOXSYS) respond better to antioxidant treatment with a change in OS and DFI. The primary outcome is the change in OS following the intervention. Secondary outcomes are morphological semen parameters and DNA fragmentation index.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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Lifestyle intervention
Diet, omega-3 fish oil (1g daily), CoQ10 (100 mg/day) and a normal Multi-vitamin, Smoking cessation, weight loss, exercise,
Omega 3
Omega 3: 1g daily for 3 months CoQ10: 100 mg daily for 3 months Multivitamin: 1 normal multivitamin tablet daily for 3 months
Interventions
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Omega 3
Omega 3: 1g daily for 3 months CoQ10: 100 mg daily for 3 months Multivitamin: 1 normal multivitamin tablet daily for 3 months
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Attending IVF treatment for unknown or male factor infertility.
Exclusion Criteria
* Azospermia
18 Years
MALE
No
Sponsors
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Peter Humaidan
OTHER
Responsible Party
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Peter Humaidan
Professor, MD
Locations
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The Fertility Clinic Skive
Skive, Central Jutland, Denmark
Countries
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References
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Humaidan P, Haahr T, Povlsen BB, Kofod L, Laursen RJ, Alsbjerg B, Elbaek HO, Esteves SC. The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study. Int Braz J Urol. 2022 Jan-Feb;48(1):131-156. doi: 10.1590/S1677-5538.IBJU.2021.0604.
Other Identifiers
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MiOxysis_Skive
Identifier Type: -
Identifier Source: org_study_id
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