Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles
NCT ID: NCT01560065
Last Updated: 2012-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
INTERVENTIONAL
Brief Summary
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Samples of seminal fluid were obtained from two groups of patients undergoing to a IVF cycle: healthy subjects and subjects with oligoasthenospermia (OA, \< 15 mil/ml). The collected samples were submitted to optic microscopy in order to evaluate semen's volume, spermatozoa's number and motility, during the initial semen analysis and after density gradient separation method; these parameters were evaluated before and after the administration of 4000mg/die of myo-inositol associated to 400 µg of folic acid for three months.
These values were compared with samples of seminal fluid of healthy patients undergoing to a IVF cycle for a female cause of infertility (control group).
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Detailed Description
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Conditions
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Study Groups
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Normospermic patients
myo-inositol + folic acid
4000mg myo-inositol + 400 µg folic acid
Oligoasthenospermic patients
myo-inositol + folic acid
4000mg myo-inositol + 400 µg folic acid
Control
No interventions assigned to this group
Interventions
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myo-inositol + folic acid
4000mg myo-inositol + 400 µg folic acid
myo-inositol + folic acid
4000mg myo-inositol + 400 µg folic acid
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* genital infections
* history of cryptorchidism or varicocele
* microorchidism
* hormonal treatment in the last six months
* alcohol intake, cigarette smoke and/or drug abuse
18 Years
40 Years
MALE
No
Sponsors
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AGUNCO Obstetrics and Gynecology Centre
OTHER
Responsible Party
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Locations
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University of Catania - Department of Surgery - Section of Obstetrics and Gynecology -Center of Physiopathology of Reproduction
Catania, , Italy
Countries
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References
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Colone M, Marelli G, Unfer V, Bozzuto G, Molinari A, Stringaro A. Inositol activity in oligoasthenoteratospermia--an in vitro study. Eur Rev Med Pharmacol Sci. 2010 Oct;14(10):891-6.
Hinton BT, White RW, Setchell BP. Concentrations of myo-inositol in the luminal fluid of the mammalian testis and epididymis. J Reprod Fertil. 1980 Mar;58(2):395-9. doi: 10.1530/jrf.0.0580395.
de Ligny W, Smits RM, Mackenzie-Proctor R, Jordan V, Fleischer K, de Bruin JP, Showell MG. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2022 May 4;5(5):CD007411. doi: 10.1002/14651858.CD007411.pub5.
Other Identifiers
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MI_IVF
Identifier Type: -
Identifier Source: org_study_id
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