Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

NCT ID: NCT02709863

Last Updated: 2016-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2017-02-28

Brief Summary

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This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Detailed Description

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Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.

Conditions

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Pituitary Adenoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Sevoflurane

1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation

Group Type ACTIVE_COMPARATOR

Sevoflurane

Intervention Type DRUG

1-1.5 MAC, inhalation route, during operation

Desflurane

1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation

Group Type ACTIVE_COMPARATOR

Desflurane

Intervention Type DRUG

1-1.5 MAC, inhalation route, during operation

Propofol

6-10 mg/kg/h, iv infusion, during operation

Group Type ACTIVE_COMPARATOR

Propofol

Intervention Type DRUG

6-10 mg/kg/h, iv infusion, during operation

Interventions

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Sevoflurane

1-1.5 MAC, inhalation route, during operation

Intervention Type DRUG

Desflurane

1-1.5 MAC, inhalation route, during operation

Intervention Type DRUG

Propofol

6-10 mg/kg/h, iv infusion, during operation

Intervention Type DRUG

Other Intervention Names

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Sevorane Suprane

Eligibility Criteria

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Inclusion Criteria

* American Society of Anesthesiologists (ASA) score I-II patients

Exclusion Criteria

* Significant cardiopulmonary disease,
* Diagnosed obstructive or restrictive pulmonary disease,
* Patients with chest wall deformities, liver or kidney failure,
* Postoperative lack of cooperation
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Istanbul University

OTHER

Sponsor Role lead

Responsible Party

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Abdulvahap Oguz

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Özlem Korkmaz Dilmen, Assoc. Prof.

Role: STUDY_DIRECTOR

Istanbul University

Locations

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Istanbul University Cerrahpasa Medical Faculty Neurosurgery Department

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Abdulvahap Oguz, MD

Role: CONTACT

00905444461924

Facility Contacts

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Özlem Korkmaz Dilmen, Assoc. Prof.

Role: primary

00905325801520

Other Identifiers

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83045809/604.01/02

Identifier Type: -

Identifier Source: org_study_id

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