Generation 100: Blood Volume and Cardiac Function in Healthy Aging

NCT ID: NCT01765816

Last Updated: 2020-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2014-11-30

Brief Summary

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Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Detailed Description

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Conditions

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Ageing

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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high intensity interval training

one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate

Group Type EXPERIMENTAL

high intensity interval training

Intervention Type BEHAVIORAL

moderate intensity training

Intervention Type BEHAVIORAL

moderate intensity training

45 minutes of moderate continuous training at 75% of maximal heart rate

Group Type ACTIVE_COMPARATOR

high intensity interval training

Intervention Type BEHAVIORAL

moderate intensity training

Intervention Type BEHAVIORAL

Interventions

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high intensity interval training

Intervention Type BEHAVIORAL

moderate intensity training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* ability to walk at least 1km,
* born in 1938,1939,1940,1941 or 1942
* Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion Criteria

* Illness or disability that precludes exercise or hinders completion of the study
* Uncontrolled hypertension
* Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
* Active cancer
* Test results indicating that study participation is unsafe
* Inclusion in other studies conflicting with participation in this one
Minimum Eligible Age

70 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Norwegian University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ulrik Wisløff, Professor

Role: STUDY_CHAIR

Norwegian University of Science and Technology

Locations

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Norwegian University of Science and Technology

Trondheim, , Norway

Site Status

Countries

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Norway

Related Links

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Other Identifiers

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Gen-100-sub1

Identifier Type: -

Identifier Source: org_study_id

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