Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
NCT ID: NCT05131217
Last Updated: 2023-11-29
Study Results
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Basic Information
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COMPLETED
NA
13 participants
INTERVENTIONAL
2022-01-14
2023-05-01
Brief Summary
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Detailed Description
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Purpose: To analyze the acute influence of HIIT on middle cerebral artery velocity (MCAv) in older adults, and to verify the positive association between MCAv and cognitive function.
Experimental Design: Recruiting 16 healthy adults age 65 and older. The study will require each participant to report to 4 visits: a screening visit, a control, a moderate intensity exercise bout, and a high intensity exercise bout. The order of the experimental visits will be randomized to each subject, and exercise bouts will be work-matched. During the experimental visits, MCAv, end-tidal CO2, MAP, and HR will be measured continuously. Vascular measures such as pulse wave analysis and pulse wave velocity will be taken pre- and post-exercise. Additionally, blood flow through the internal carotid artery and cognitive measures (n-back test) will be measured and administered pre-exercise, and at 15 mins, 30 mins, and 45 mins post-exercise. A two-way repeated measures ANOVA will be used to determine significant differences for time (pre vs. post measures) x condition (control/moderate/HIIT).
Results: In the process of collecting data.
Implications: If the study is successful in its findings, this could change how exercise is prescribed to older adults. It could also lead to the question regarding if a greater exercise stimulus (i.e. SIT) may be even more beneficial for these individuals.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Acute bout of Continuous Moderate Intensity Exercise
Acute bout of Continuous Moderate Intensity Exercise
In this experimental intervention subjects will cycle continuously at moderate intensity (VO2 corresponding to lactate threshold) until a 200 kcal equivalent energy expenditure is reached.
Acute bout of High Intensity Interval Training (HIIT)
Acute bout of High Intensity Interval Training
In this experimental invention subjects will alternate between 1 minute of high intensity cycling (watts corresponding to 85% VO2peak) and 1 minute of low intensity cycling (watts corresponding to 35-40% VO2peak) until a 200 kcal equivalent energy expenditure is reached.
Control
Control
In this intervention placebo, subjects will lay down on a flat, soft surface for 30 minutes in a dimly light room. They will not be allowed to use any electronic devices or read during this time to avoid potentially influencing continuous data recording.
Interventions
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Acute bout of Continuous Moderate Intensity Exercise
In this experimental intervention subjects will cycle continuously at moderate intensity (VO2 corresponding to lactate threshold) until a 200 kcal equivalent energy expenditure is reached.
Acute bout of High Intensity Interval Training
In this experimental invention subjects will alternate between 1 minute of high intensity cycling (watts corresponding to 85% VO2peak) and 1 minute of low intensity cycling (watts corresponding to 35-40% VO2peak) until a 200 kcal equivalent energy expenditure is reached.
Control
In this intervention placebo, subjects will lay down on a flat, soft surface for 30 minutes in a dimly light room. They will not be allowed to use any electronic devices or read during this time to avoid potentially influencing continuous data recording.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Comfortable with experiencing exercise-induced fatigue
* Willingness and ability to comply with scheduled visits and study procedures
* Able to provide consent on their own behalf
* Type 2 Diabetics accepted
Exclusion Criteria
* VO2max below 18 ml/kg/min in men, 15ml/kg/min in women (minimum thresholds for independent living seniors)
* Inability of study staff to acquire signal from the MCA using TCD
* Diagnosis of mild cognitive impairment, Parkinson's Disease, Alzheimer's Disease, multiple sclerosis, or psychiatric illness (unless mild depression or anxiety)
* History of brain damage/stroke/concussions
* Cardiovascular Disease, Pulmonary Disease, or dependence of supplemental O2
* Type 2 Diabetics who aren't cleared by the study physician during the first screening visit (HbA1C \> 8.5%)
* Neuromuscular or musculoskeletal dysfunctions impairing one from cycling
* Changes in vasoactive medication dose or quantity, recently prior to or during the study time course, or inability to maintain regular timed ingestion of vasoactive medication
* Currently involved in Estrogen or Testosterone Replacement Therapy
* Unable to abstain from food consumption (3hrs), caffeine/alcohol consumption (12hrs), and vigorous exercise (24hrs) prior to experimental procedures
65 Years
ALL
Yes
Sponsors
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University of Virginia
OTHER
Responsible Party
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Jason Allen
Professor of Exercise Physiology at the University of Virginia, Director of the Exercise Physiology Graduate Program & Co-Director of the Applied Metabolism & Physiology Lab
Principal Investigators
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Jason Allen, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Virginia
Locations
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University of Virginia; Kinesiology Labs
Charlottesville, Virginia, United States
Countries
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References
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Other Identifiers
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HSR200454
Identifier Type: -
Identifier Source: org_study_id