The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2009-02-28

Brief Summary

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* ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
* The set of the PEEP (low or high levels) remains unclear : it seems that some patients need low levels of PEEP whereas anther need high levels; but there is no validated data that can discriminate them.
* We hypothesized that patients with low levels of EVLW ( measured with the Picco® system ) need low level of PEEP to ameliorate their oxygenation ( measured with the PaO2/FiO2 ratio ) whereas patients with high levels of EVLW) need high levels of PEEP.

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Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1: High level PEEP

No interventions assigned to this group

2: Low level PEEP

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age\>18;
* ARDS criteria.

Exclusion Criteria

* severe pulmonary hypertension;
* chronic right ventricular failure;
* pulmonary embolism;
* tricuspidian valvulopathy;
* history of spontaneous pneumothorax;
* severe emphysema;
* bronchomalacia;
* recent pulmonary surgery;
* BMI\>40;
* Interstitial pulmonary fibrosis;
* End of life;
* Chronic neuromyopathie;
* Recent neurosurgery or intracranian hypertension;
* Pregnancy.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No