Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS

NCT ID: NCT05474196

Last Updated: 2025-02-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-01

Study Completion Date

2025-09-30

Brief Summary

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Intubated patients with the acute respiratory distress syndrome (ARDS) are usually treated with protective ventilation limiting plateau pressure below 30 centimeter of water (cmH2O) and, if possible, a driving pressure under 15 cmH2O. However, these airway pressures might not reflect the actual pressure applied to the lung. Transpulmonary pressure is the difference between airway pressure and pleural pressure, the latter is estimated by the esophageal pressure, and so it better reflects the ventilatory induced lung injury (VILI).

One of the consequences of the VILI is a increase of pulmonary edema and it could be estimated by the extravascular lung water, obtained by trans-pulmonary thermodilution.

So it could exist a link between the driving trans-pulmonary pressure and the extravascular lung water.

Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Acute respiratory distress syndrome (ARDS)
* Monitoring with a transpulmonary thermodilution device
* Esophageal pressure monitoring

Exclusion Criteria

* Legal protection measures
* Pregnancy
* Contra-indications of esophageal catheter : esophageal varicose, severe coagulopathy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bicetre Hospital

OTHER

Sponsor Role lead

Responsible Party

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Tai PHAM

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tài Pham, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Hôpital Bicêtre

Locations

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Medical Intensive Care Unit, Bicêtre Hospital

Le Kremlin-Bicêtre, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Tài Pham, MD, PhD.

Role: CONTACT

+33145217245

Facility Contacts

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Tài Pham, MD

Role: primary

+33145217245

Other Identifiers

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2022-A01289-34

Identifier Type: -

Identifier Source: org_study_id

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