Transpulmonary Pressure in Right Ventricle Protection of ARDS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-01

Study Completion Date

2025-12-31

Brief Summary

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To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

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Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome Acute Cor Pulmonale

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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PTP group

Group Type EXPERIMENTAL

mechanical ventilation strategy guided by transpulmonary pressure

Intervention Type PROCEDURE

Mechanical ventilation parameters adjust guided by transpulmonary pressure monitoring. For pressure assist control or volumn assit control mode; inspiratory pressure or volumn setting needs to maintain Ppeak less than 25 cm H2O; PEEP was set at such a level that expiratory Ptp stayed between 0 and 5 cm H2O.

Control group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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mechanical ventilation strategy guided by transpulmonary pressure

Mechanical ventilation parameters adjust guided by transpulmonary pressure monitoring. For pressure assist control or volumn assit control mode; inspiratory pressure or volumn setting needs to maintain Ppeak less than 25 cm H2O; PEEP was set at such a level that expiratory Ptp stayed between 0 and 5 cm H2O.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* duration of invasive mechanical ventilation less than 72 hours;
* meet the diagnostic criteria of Berlin definition for ARDS;
* age older than 18

Exclusion Criteria

* esophageal surgery or damage;
* cardiac surgery;
* severe bronchopleural fistula;
* serious arrhythmia; pneumothorax;
* tricuspid stenosis;
* heparin allergy;
* chronic pulmonary heart disease

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No