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Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

NCT ID: NCT05442073

Last Updated: 2022-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

18 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-01

Study Completion Date

2022-06-29

Brief Summary

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Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

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Detailed Description

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Conditions

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ARDS, Human PEEP, Occult Esophageal and Pleural Pressure

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Type I: ΔPes≥30%ΔPEEP

PEEP adjustment

Intervention Type OTHER

adjusting PEEP about 3-5cmH2O (increase or decrease)

Type II: ΔPes<30%ΔPEEP

PEEP adjustment

Intervention Type OTHER

adjusting PEEP about 3-5cmH2O (increase or decrease)

Interventions

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PEEP adjustment

adjusting PEEP about 3-5cmH2O (increase or decrease)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\- aged over 18 all the moderate to severe ARDS patients invasive mechanical ventilation

Exclusion Criteria

* aged\<18 contraindication to esophageal catheter
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shuyang Zhang, MD

Role: STUDY_CHAIR

Peking Union Medical College Hospital

Locations

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Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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ZS-2458

Identifier Type: -

Identifier Source: org_study_id

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