Evaluation of POC Lung Ultrasound Combined With Pressure-volume Curve to Titration Adjust PEEP for ARDS Lung Recruitment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-01

Study Completion Date

2018-09-01

Brief Summary

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Using lung ultrasound re-aeration score(LUS-RAS) combined with pressure-volume curve(PVC) adjust maintain positive end-expiratory pressure(PEEP) after recruitment maneuver, to achieve real-time adjustment, reduce ventilation-associated lung injury and the purpose of effective lung recruitment.

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Detailed Description

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The traditional method, set PEEP according to PVC in ARDS mechanical ventilation, lacks morphological evaluation. For point-of-care lung ultrasound(POC-LUS) is non-invasive, real-time, visualization, no need transport patients, getting more and more attention in the ARDS treatment. It has been reported that LUS-RAS is a meaningful assessment in recruitment maneuver. This study will combine POC-LUS with PVC in set the initial peep, and then dynamic record LUS-RAS to feedback regulate PEEP. Using the POC-LUS and maximum oxygenation method to assess lung recruitment effect in experimental group and control group prospectively. The ventilator parameters, state of hemodynamic, arterial blood gas(ABG) in each group will be recorded; Statistical methods will be performed in term to understand the correlation.

Conditions

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Acute Respiratory Distress Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Maximum Oxygenation

Using PVC to set the initial peep, check ABG real-time, and according to PaO2+PaCO2≥400mmHg whether or not to adjust maintain PEEP.

Group Type ACTIVE_COMPARATOR

Maximum Oxygenation

Intervention Type DIAGNOSTIC_TEST

Adjust PEEP real-time in term of PaO2+PaCO2≥400mmHg whether or not.

Lung Ultrasound Re-aeration Score

Combine POC-LUS with PVC in set the initial peep, and then dynamic record LUS-RAS to feedback regulate PEEP.

Group Type EXPERIMENTAL

Lung Ultrasound

Intervention Type DEVICE

Adjust PEEP real-time in term of LUS-RAS chang.

Interventions

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Lung Ultrasound

Adjust PEEP real-time in term of LUS-RAS chang.

Intervention Type DEVICE

Maximum Oxygenation

Adjust PEEP real-time in term of PaO2+PaCO2≥400mmHg whether or not.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patient aged 18 years and older
* ARDS patients with invasive mechanical ventilation

Exclusion Criteria

* Intracranial hypertension
* Pneumothorax and mediastinal emphysema
* Severe hypoxemia (oxygenation index \<100)
* Hemodynamic instability
* Chest deformity or surgical history
* Affect Lung-ultrasound conditions: subcutaneous emphysema, chest wound etc.

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No