Physiological Studies in the Prone Position in Patients With ARDS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-01

Study Completion Date

2025-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to observe the changes of physiological indicators such as ventilation and oxygenation in the prone position of ARDS patients, to observe the change trend of each patient's indicators, and to observe whether different trends of indicators predict different prognosis of patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Extravascular Lung Water on Prone Position Efficacy in Patients With ARDS

NCT04635267

Acute Respiratory Distress Syndrome Acute Respiratory Distress Syndrome in Adult or Child

UNKNOWN

Practices of Prone Positioning Ventilation in Patients With Moderate-to-Severe ARDS in Intensive Care Units: A Registry-Based Observational Study

NCT07284888

Acute Respiratory Distress Syndrome

RECRUITING

Effect of PP in Patients With Ultra-low VT

NCT06215209

Acute Respiratory Distress Syndrome Prone Position Tidal Volume

RECRUITING

Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS

NCT06854627

Acute Respiratory Distress Syndrome

RECRUITING NA

Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.

NCT05056090

ARDS Acute Respiratory Distress Syndrome Intensive Care Unit +1 more

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

PP has been shown to effectively improve the prognosis of patients with severe ARDS, but not all patients with ARDS can benefit from PP, and the implementation of the PP has a certain clinical risks and side effects, we lack a convenient predictors to guide doctors to determine whether patients should implement the PP. Clinical usually observe the P/F improved as whether PP treatment effective reference, but there are literature points out that the rising P/F after PP can not predict the better prognosis. one of the mechanisms for ARDS patients benefit from PP is proved to be improve V/Q, the change of the V/Q may determine whether the PP treatment effectively is an important indicator. PaO2:FiO2 ratio was usually used to evaluate the effect of PP, but some studies did not support this conclusion. PP has been shown to change ventilation-perfusion ratio, dead space may be better physiological indicators, simplify dead space ratio and Ventilatory ratio can be easily accessed at bedside and is associated with mortality of patients with ARDS. The purpose of this study is to observe the predictive value of P/F, VD-etCO2/VT, and VR on the treatment effect of ARDS undergoing PP.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Respiratory Distress Syndrome Mechanical Ventilation Prone Positioning

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Intubated patients
2. Undergoing mechanical ventilation
3. Moderate to severe ARDS
4. Undergoing prone positioning
5. Age≥18 years old

Exclusion Criteria

1. Pregnant
2. Cardiac structural shunt
3. Extracorporeal membrane oxygenation performed
4. Undergo extracorporeal CO2 removal
5. Pulmonary embolism
6. Other situation that may affect the accuracy of PetCO2 monitoring
7. Prone positioning session less than 10 hours

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No