Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

NCT ID: NCT01652612

Last Updated: 2013-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

99 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2013-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

One Lung Ventilation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control

zero PEEP

Group Type NO_INTERVENTION

No interventions assigned to this group

OLV strategy: PEEP

1\. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery

Group Type EXPERIMENTAL

PEEP

Intervention Type OTHER

8 cmH2O PEEP throughout the period of OLV and 2nd TLV

OLV strategy: PEEP followed by AR

1. alveolar recruitment strategy before one lung ventilation
2. 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery

Group Type EXPERIMENTAL

PEEP

Intervention Type OTHER

8 cmH2O PEEP throughout the period of OLV and 2nd TLV

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

PEEP

8 cmH2O PEEP throughout the period of OLV and 2nd TLV

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ASA I-II
* age: 20-75 years

Exclusion Criteria

* moderate to severe impaired respiratory function,
* heart failure,
* patients' refusal
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Yonsei University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Yongseon Choi

assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Yongseon Choi

Role: PRINCIPAL_INVESTIGATOR

Assistant professor

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Yong Seon Choi

Seoul, Seoul, South Korea

Site Status

Countries

Review the countries where the study has at least one active or historical site.

South Korea

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

4-2011-0301

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Protective Ventilation Strategy
NCT03234621 COMPLETED NA