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Effects of Different I:E Ratio on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position

NCT ID: NCT01499212

Last Updated: 2011-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2011-12-31

Brief Summary

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The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.

Detailed Description

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Increasing inspiratory time(e.g. Inverse ratio ventilation) has been known that had advantage of alveolar recruitment, preventing of ateletasis. On the contrary, it has disadvantange of intrinsic PEEP, air trapping. There is few study on one lung ventilation in lateral decubitus position about this ventilation method. We were going to investigate effecf of this ventilation method.

Conditions

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Lung Cancer Lung Lobectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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I:E ratio 1:1

Group Type EXPERIMENTAL

I:E ratio

Intervention Type PROCEDURE

I:E ratio 1:1 Volume controlled ventilation TV:8ml/kg EtCO2:35-40mmHg

Interventions

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I:E ratio

I:E ratio 1:1 Volume controlled ventilation TV:8ml/kg EtCO2:35-40mmHg

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* ASA physical status class I, II
* Use of Double lumen tube
* Unilateral lung lobectomy

Exclusion Criteria

* COPD
* CAOD
* Unstable hemodynamic status
* Peak airway pressure \> 30mmHg (Two lung ventilation)
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Young Jun Oh, MD,PhD

Role: STUDY_CHAIR

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea

Locations

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Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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1-2011-0058

Identifier Type: -

Identifier Source: org_study_id