Ventilation Strategy for the Elderly Patients in Prone Position
NCT ID: NCT04520893
Last Updated: 2021-02-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
45 participants
INTERVENTIONAL
2020-10-22
2021-03-31
Brief Summary
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Detailed Description
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1. All patients were ventilated by an anaesthesia ventilator (Zeus, Dräger, Lübeck, Germany) under general anesthesia.
2. Ventilation strategy:
* Pressure controlled ventilation volume guaranteed (PCV-VG) mode or volume control ventilation (VCV) mode
* tidal volume 6-8 mL/kg (predicted body weight)
* Inspiratory/expiratory (I/E) ratio 1:1.5
* Inspired oxygen concentration (FIO2) 0.5 with air
* 3.0 L/min of inspiratory fresh gas flow
* Positive end-expiratory pressure (PEEP) of 5 cm H2O
* Respiratory rate (RR) of 10 to 14 min-1
3. After prone positioning and hemodynamic condition was stabilized, patients were ventilated with VCV, PCV-VG mode, VCV with pause following a randomized order, previously determined for each patient. Before each ventilator setting was started, lung recruitment maneuvers were performed to set the lungs to a defined baseline status.
* ventilation order : one of the following examples is taken by randomization.
VCV 15 min -- VCV pause 15min -- PCV-VG 15min
VCV 15 min -- PCV-VG 15min -- VCV pause 15min
VCV pause 15min -- VCV 15 min -- PCV-VG 15min
VCV pause 15min -- PCV-VG 15min -- VCV 15 min
PCV-VG 15min -- VCV 15 min -- VCV pause 15min
PCV-VG 15min -- VCV pause 15min -- VCV 15 min
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
SUPPORTIVE_CARE
NONE
Study Groups
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VCV pause
volume controlled ventilation with pause time 30%
ventilator setting vcv with pause
ventilator setting vcv with pause
VCV
volume controlled ventilation (without pause)
ventilator setting vcv
ventilator setting vcv without pause
PCV-VG
pressure controlled ventilation - volume guaranteed
ventilator setting pcv-vg
ventilator setting with pcv-vg
Interventions
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ventilator setting vcv with pause
ventilator setting vcv with pause
ventilator setting vcv
ventilator setting vcv without pause
ventilator setting pcv-vg
ventilator setting with pcv-vg
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* chronic obstructive pulmonary disease
* respiratory infection
65 Years
85 Years
ALL
No
Sponsors
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Eunhee Chun
OTHER
Responsible Party
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Eunhee Chun
Assistant professor
Principal Investigators
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Eunhee Chun, MD.,PhD.
Role: PRINCIPAL_INVESTIGATOR
Hallym University Kangnam Sacred Heart Hospital
Locations
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Hallym University Kangnam Sacred Hospital
Seoul, , South Korea
Countries
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Other Identifiers
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2020-03-010
Identifier Type: -
Identifier Source: org_study_id
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