Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
NCT ID: NCT03657368
Last Updated: 2025-08-27
Study Results
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View full resultsBasic Information
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COMPLETED
NA
2860 participants
INTERVENTIONAL
2018-09-03
2020-10-23
Brief Summary
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Detailed Description
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Ventilation parameters will be designated at the beginning of each study week. However, clinicians will be free to adjust to whatever ventilation settings they believe is optimal in individual patients to ensure oxygenation and patient safety.
Conditions
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Study Design
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NON_RANDOMIZED
FACTORIAL
PREVENTION
SINGLE
Study Groups
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Low tidal volume and low PEEP
Ventilation parameters will be set at tidal volume = 6 ml/ kg predicted body weight, and PEEP = 5 cm water (H2O).
Low tidal Volume
Tidal volume = 6 ml/kg predicted body weight
Low PEEP
PEEP = 5 cm H2O
Low tidal volume and high PEEP
Ventilation parameters will be set at tidal volume = 6 ml/kg predicted body weight, and PEEP = 8 cm H2O.
Low tidal Volume
Tidal volume = 6 ml/kg predicted body weight
High PEEP
PEEP = 8 cm H2O
High tidal volume and low PEEP
Ventilation parameters will be set at tidal volume = 10 ml/kg predicted body weight, and PEEP = 5cm H2O.
High tidal Volume
Tidal volume = 10 ml/kg predicted body weight
Low PEEP
PEEP = 5 cm H2O
High tidal volume and high PEEP
Ventilation parameters will be set at tidal volume = 10 ml/kg predicted body weight, and PEEP = 8cm H2O.
High tidal Volume
Tidal volume = 10 ml/kg predicted body weight
High PEEP
PEEP = 8 cm H2O
Interventions
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Low tidal Volume
Tidal volume = 6 ml/kg predicted body weight
High tidal Volume
Tidal volume = 10 ml/kg predicted body weight
Low PEEP
PEEP = 5 cm H2O
High PEEP
PEEP = 8 cm H2O
Eligibility Criteria
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Inclusion Criteria
* General anesthesia with endotracheal intubation.
Exclusion Criteria
* Intubation before induction of anesthesia.
18 Years
ALL
No
Sponsors
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The Cleveland Clinic
OTHER
Responsible Party
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Principal Investigators
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Alparslan Turan, MD
Role: PRINCIPAL_INVESTIGATOR
The Cleveland Clinic
Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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18-001
Identifier Type: -
Identifier Source: org_study_id
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