The Effect of Pressure Controlled Ventilation on the Pulmonary Mechanics in Prone Position Using the Wilson Frame: A Comparison With Volume Controlled Ventilation

NCT ID: NCT01272700

Last Updated: 2012-02-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-08-31
• Study Completion Date: 2011-01-31

Brief Summary

Prone position in spinal surgery can increase airway pressure and decrease dynamic lung compliance by a frame used for postural stabilization. Also, it can increase hemodynamic instability such as reduced blood pressure by aggravating cardiac index.

Former study shows pressure controlled ventilation on the pulmonary mechanics can improve alveolar use and oxygenation than volume controlled ventilation. The latter one means controlling a patient's breathing completely through tidal volume and set breathing rate. This could be useful for the patients not possible to breath by themselves because it guarantees the perfect breathing.

The pressure controlled ventilation is used when there is a possibility to change a patient's environment. The pressure will be maintained steadily, but volume and flux will be changed. That means through the pressure already set, the whole breathing will be maintained from the beginning to end. If a patient's resistance is increased, the volume will be decreased even though the way of blood pressure control is same. However, the tidal volume per minute can be controlled somewhat and barotrauma can be decreased by controlling respiratory rate. Through this study, we are expecting the pressure controlled ventilation in prone position can improve lung mechanics and oxygenation.

Conditions

Herniation of Lumbar Vertebral Disc

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: DOUBLE

Study Groups

PCV

Peak airway pressure were set to deliver a tidal volume of 10 ml/kg of ideal body weight

Group Type: EXPERIMENTAL

volume control

Intervention Type: PROCEDURE

Volume controlled ventilation of tidal volume 10 ml/kg

VCV

After anesthetic induction, anesthesia maching were set to deliver a tidal volume of 10 ml/kg of ideal body weight

Group Type: ACTIVE_COMPARATOR

pressure control

Intervention Type: PROCEDURE

Pressure controlled ventilation for peak airway pressure to deliver tidal volume 10 ml/kg.

Interventions

volume control

Volume controlled ventilation of tidal volume 10 ml/kg

Intervention Type: PROCEDURE

pressure control

Pressure controlled ventilation for peak airway pressure to deliver tidal volume 10 ml/kg.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• scheduled for lumbar spine surgery under general anaesthesia

Exclusion Criteria

• Patients with coronary artery occlusive disease
• morbid obesity (body mass index ≥ 30 kg/m2)
• cerebrovascular disease and major obstructive or restrictive pulmonary disease

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yonsei University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Severance Hospital

Seoul, , South Korea

Countries

South Korea

Other Identifiers

4-2010-0201

Identifier Type: -

Identifier Source: org_study_id