Effects of Extravascular Lung Water on Prone Position Efficacy in Patients With ARDS
NCT ID: NCT04635267
Last Updated: 2020-11-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2021-01-01
2022-05-01
Brief Summary
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Prone position will increase blood oxygenation in 75% of the cases and will be persistant in half of the cases. Unfortunately, no clinical criteria has been found correlated with efficacy. The quantity of lung edema, with increased lung weight, could be a determinant factor of efficacy and the persistance of the efficacy. EVLWi, assessed with the PiCCO2 device, reflects the quantity of fluid accumulated in interstitial and alveolar spaces.
The hypothesis is that patients with higher EVLWi will have less efficacy of prone position in oxygenation and also that the beneficial effects of prone position will last shorter compared to patients with lower EVLWi.
Detailed Description
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Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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patients with ARDS
Prone position in patients with ARDS
Transpulmonary thermodilution, arterial blood gas and recruitment/inflation calculation will be made every 8 hours: at baseline (just before prone position), after eight hours of prone position, after 16 hours of prone position (end of prone position), after 24 hours ( 8 hours after the end of prone position).
Interventions
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Prone position in patients with ARDS
Transpulmonary thermodilution, arterial blood gas and recruitment/inflation calculation will be made every 8 hours: at baseline (just before prone position), after eight hours of prone position, after 16 hours of prone position (end of prone position), after 24 hours ( 8 hours after the end of prone position).
Eligibility Criteria
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Inclusion Criteria
* Presence of acute respiratory distress syndrome
* Decision to perform prone position according to the physician in charge of the patient
* Hemodynamic monitoring with a PiCCO2 device (Pulsion Medical Systems, Feldkirchen, Allemagne)
Exclusion Criteria
* Patient under a tutelage measure or placed under judicial protection
* Known pregnancy
* Currently receiving ECMO therapy
18 Years
99 Years
ALL
No
Sponsors
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Bicetre Hospital
OTHER
Responsible Party
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Christopher Lai
doctor
Central Contacts
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Other Identifiers
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2020-A03094-35
Identifier Type: -
Identifier Source: org_study_id