Prone Position and Renal Resistive Index

NCT ID: NCT04286490

Last Updated: 2025-01-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-30

Study Completion Date

2022-06-30

Brief Summary

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Patients suffering from Acute Respiratory Distress Syndrome (ARDS) with a prone position (PP) indication will benefit from measurements of renal resistive index, intra-abdominal pressure (IAP), urinary oxygen tension (uPO2) and ventilatory mechanics in supine position (baseline IAP), after 2 hours in PP at the current IAP value, thirty minutes after patients' abdomen suspension in order to resume baseline IAP and after patients' are turned back to supine position.

Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome Acute Kidney Injury Prone Position Intra-Abdominal Hypertension

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Prone position

Group Type EXPERIMENTAL

Prone position

Intervention Type OTHER

Abdomen suspension in prone position

Interventions

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Prone position

Abdomen suspension in prone position

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* ARDS patients according to Berlin criteria, intubated, mechanically ventilated
* with PaO₂/FiO₂ \< 150 mmHg,
* neuromuscular blockade
* with an indication of PP done by the physician in charge
* possibility to differ PP for one hour
* patients should be hemodynamically stable since at least 4 hours

Exclusion Criteria

* Pregnant or breast-feeding women
* legal protection, no social security affiliation
* PP contra-indication
* nasogastric tube contra-indication
* extra corporeal membrane oxygenation
* acute kidney injury at inclusion according to K-DIO criteria, chronic kidney disease defined as an estimated glomerualr filtration rate less than 30 ml/min/1.73m², kidney transplantation, renal artery stenosis, solitary kidney, albuminuria \> 1.25 mg/ml
* cardiac arrhythmia
* obesity
* advanced cirrhosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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French Society for Intensive Care

OTHER

Sponsor Role collaborator

Act For Chronic Diseases

OTHER

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hospital Grenoble University

Grenoble, , France

Site Status

Countries

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France

Other Identifiers

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38RC19.265

Identifier Type: -

Identifier Source: org_study_id

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