Effect of Early Implementation of Prone Positioning

NCT ID: NCT06287554

Last Updated: 2024-03-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 70 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-03-04
• Study Completion Date: 2022-04-20

Brief Summary

Background and objective: The ramifications of early lung protective measures and prone positioning on the ICU length of stay rates of participants admitted to the ICU with acute respiratory distress syndrome amid the COVID-19 pandemic constitute a pivotal examination. The study aims to identify the effect of early prone positioning on the length of stay, discharge rate, and number of tracheostomized patients in the ICU.

Detailed Description

Background and objective: The ramifications of early lung protective measures and prone positioning on the ICU length of stay rates of participants admitted to the ICU with acute respiratory distress syndrome amid the COVID-19 pandemic constitute a pivotal examination. The study aims to identify the effect of early prone positioning on the length of stay, discharge rate, and number of tracheostomized patients in the ICU.

Methodology: This retrospective study was conducted on critically ill patients needing mechanical ventilation with lung protective strategy and admitted to the Intensive Care Units of Al-Azhar University Hospitals between March 2020 to April 2022. All patients in the study were interpreted retrospectively by examining the patient's records. Group A (n:39) included patients who had been early placed in prone positions within 24 hours of intubation, and Group B (n:31) included patients who had not been placed in prone positions. All patients received a lung protective strategy for ARDS. In both groups, PaO2, PaCo2, PH, SpO2, and PaO2/FiO2 ratio were checked initially and later every 24 hours for 6 days. All patients were evaluated for the total days of both hospital and ICU length of stay, number of successful discharges to home from the hospital, and the total number of tracheostomized patients.

Conditions

Severe Acute Respiratory Syndrome

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: OTHER

Study Groups

Group A

Group A (n:39) included patients who had been early placed in prone positions within 24 hours of intubation

PRONE POSITION

Intervention Type: OTHER

early placed in prone positions within 24 hours of intubation

Group B

Group B (n:31) included patients who had not been placed in prone position

No interventions assigned to this group

Interventions

PRONE POSITION

early placed in prone positions within 24 hours of intubation

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• All patients of both sexes.
• Aged from 18 to 70 years.
• Body Mass Index (BMI) from 25 to 35 kg/m2.
• Critically ill due to ARDS resulting from COVID-19 pneumonia.

Exclusion Criteria

• Patients who spent more than 24 hours on mechanical ventilators before enrolment in the study.
• Patients who died within the first 24 hours of presentation.
• Patients with advanced cancer.
• Pregnant patients.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Al-Azhar University

OTHER

Sponsor Role: collaborator

Zulekha Hospitals

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

SAMEH H SEYAM, PHD

Role: STUDY_CHAIR

Consultant critical care

Locations

Al-Azhar faculty of medicine

Cairo, , Egypt

Countries

Egypt

Other Identifiers

404/2024

Identifier Type: -

Identifier Source: org_study_id