MedDataX Logo

Safety of Low PEEP Maneuvers During ARDS Management

NCT ID: NCT05922969

Last Updated: 2024-07-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-05-28

Study Completion Date

2024-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown.

The aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Determination of the Best Positive End-expiratory Pressure (PEEP)

NCT03969407

Positive Expiratory Pressure Acute Respiratory Distress Syndrome
COMPLETED

Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome

NCT01256333

Respiratory Distress Syndrome, Adult
COMPLETED

Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS

NCT05474196

Acute Respiratory Distress Syndrome
RECRUITING

Lung Imaging for Ventilatory Setting in ARDS

NCT02149589

ARDS
COMPLETED NA

Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS

NCT05524558

ARDS, Human Ventilation Therapy; Complications Alveolar; Disorder
UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Respiratory Distress Syndrome Positive End Expiratory Pressure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age : \> 18 yo

Exclusion Criteria

* refusal to participate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Centre Hospitalier VALENCIENNES

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

CHU Amiens

Amiens, , France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Yoann Zerbib, MD

Role: CONTACT

[email protected]
03 22 08 77 23

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Yoann Zerbib, MD

Role: primary

[email protected]
03 22 08 77 23

Yoann Zerbib

Role: backup

[email protected]
03 22 08 77 23

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PI2021_843_0165

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Optimization of PEEP for Alveolar Recruitment in ARDS
NCT01949272 COMPLETED
Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.
NCT05056090 UNKNOWN NA
Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients
NCT03202641 TERMINATED NA
Trans-pulmonary Pressure in ARDS
NCT02416037 COMPLETED NA
The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)
NCT00714987 WITHDRAWN
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
NCT04386369 COMPLETED
Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS
NCT05442073 COMPLETED
Hemodynamic and Cardiac Effects of Individualized PEEP Titration Using Esophageal Pressure Measurements in ARDS Patients
NCT02617914 WITHDRAWN
PEEP in Patients With Acute Respiratory Failure
NCT04912960 RECRUITING
Transpulmonary Driving Pressure in ARDS COVID19 Patients
NCT04381286 UNKNOWN
Effects of Ventilation With Tidal Volume Adjusted on Driving Pressure on Ventilation/Perfusion Ratios and Hemodynamics in ARDS
NCT06817629 NOT_YET_RECRUITING
The Influence of Different PEEP Levels After Recruitment Maneuvre on the Effect of Alveolar Recruitment Maintenance and Patients' Cardiac Function
NCT07161466 NOT_YET_RECRUITING NA
Clinical Impact of Different Duration Prone Postition Treatment for Patients With ARDS.
NCT04391387 COMPLETED NA
Effect of Lung Protective One-lung Ventilation With Fix and Variable PEEP on Oxygenation and Outcome
NCT03968120 COMPLETED NA
The Strategy of "Pulmonary Opening by Titration of Positive End-expiratory Pressure" Means of a Pulmonary Recruitment Maneuver in Patients With Acute Respiratory Distress Syndrome: for Which Patients?
NCT04028336 TERMINATED NA
Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers.
NCT00263146 TERMINATED NA
A Non-invasive Evaluation of Kidney-Lung Interactions
NCT03747731 UNKNOWN
Improvement of Lung and Thoracic Compliance in ARDS Patients in Prone Position by Using Inflatable Air Bag
NCT05515484 RECRUITING PHASE2
Effects of Sedation on Transpulmonary Pressure and Lung Homogenous
NCT03237806 COMPLETED NA
LIght Sedation Pressure Support
NCT03783468 WITHDRAWN NA
Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient
NCT00538161 COMPLETED NA
Mechanical Ventilation-induced Acute Kidney Injury [AKI]
NCT06638255 NOT_YET_RECRUITING NA
Physiological Studies in the Prone Position in Patients With ARDS
NCT06586736 RECRUITING
Analysis of Advanced Physiological Ventilatory Parameters During Spontaneous Breathing Effort in Patients with Acute Hypoxemic Respiratory Failure
NCT06490523 COMPLETED
Ultra Protective Ventilation Without Extracorporeal Circulation in Severe ARDS Patients (VT4ARDS)
NCT02816372 COMPLETED NA