Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS

NCT ID: NCT05524558

Last Updated: 2022-09-01

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 34 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-02-01
• Study Completion Date: 2022-11-30

Brief Summary

The corner stone of the treatment of ARDS is mechanical ventilation with high levels of positive end-expiratory pressure, also called PEEP. A high level of PEEP is recommended and frequently used. But PEEP can lower cardiac output and contribute to circulatory failure during mechanical ventilation. Nevertheless, in theory, the PEEP-induced pulmonary vascular resistance (PVR) increase could depend on the level of alveolar recruitment, but it has never been proven. Thus, the aim of this study is to determine the relation between the high-PEEP induced PVR and the alveolar recruitment or overdistension.

Detailed Description

During acute respiratory distress syndrome (ARDS) the application of positive end-expiratory pressure (PEEP) prevents expiratory alveolar collapse. However, it can induce a predominant recruitment effect or, on the contrary, alveolar overdistension. The recruitment/overdistension ratio can be easily assessed using R/I ratio (or recruitment-to-inflation ratio). However, PEEP is likely to lower cardiac output and contribute to the cardiovascular failure that often occurs in patients with ARDS. Among its hemodynamic effects, PEEP is likely to increase pulmonary vascular resistance and, thus, right ventricular afterload. In theory, this effect should only occur if PEEP over-distends the lung volume, compressing the "extra-alveolar" vessels and increasing their resistance. However, this different effect of PEEP on pulmonary vascular resistance depending on the degree of recruitment or overdistension has never been demonstrated during ARDS in humans.

We retrospectively studied data collected from patients with ARDS, monitored by pulmonary artery catheter (PAC), to eventually find a correlation between the high PEEP-induced PVR increase and recruitement/overdistension profile.

Conditions

ARDS, Human; Ventilation Therapy; Complications; Alveolar; Disorder

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Pulmonary artery catheter

PAC already in place

Intervention Type: DEVICE

Esophagal pressure

Esophagal pressure already in place

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• ARDS diagnosed
• Invasive mechanical ventilation
• Pulmonary artery catheter already in place
• Esophagal pressure measure

Exclusion Criteria

• Pregnancy
• Prone position at inclusion
• Legal protection measures

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Bicetre Hospital

OTHER

Sponsor Role: lead

Responsible Party

Xavier Monnet

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Bicetre Hospital

Le Kremlin-Bicêtre, Île-de-France Region, France

Site Status: RECRUITING

Countries

France

Central Contacts

Xavier Monnet, Pr

Role: CONTACT

xavier.monnet@aphp.fr

01 45 21 35 39

Facility Contacts

Xavier Monnet, Pr

Role: primary

xavier.monnet@aphp.fr

01 45 21 35 39

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Other Identifiers

2022-A00058-35

Identifier Type: -

Identifier Source: org_study_id