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Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on Alveolar Recruitment and Distension by CT-scan in Early ARDS Patients

NCT ID: NCT02885584

Last Updated: 2016-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-31

Study Completion Date

2017-05-31

Brief Summary

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High frequency percussive ventilation (HFPV) is a high frequency ventilation mode in which high frequency pulses accumulate to generate a low frequency tidal volume at a controlled airway pressure. Previous studies have suggested a protective effect of HFPV on lung injury. The goal of our study is to compare, in early ARDS patients, the effects of conventional mechanical ventilation and of high frequency percussive ventilation on alveolar recruitment and distension evaluated by CT-scan

Detailed Description

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Conditions

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ARDS

Keywords

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Mechanical ventilation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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Transpulmonary pressure controlled mechanical ventilation

transpulmonary pressure will be used for ventilation settings

Group Type EXPERIMENTAL

High frequency percussive ventilation

Intervention Type DEVICE

Conventional pressure-controlled mechanical ventilation

transpulmonary pressure will not be used for ventilation settings

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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High frequency percussive ventilation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient undergoing invasive ventilation for more than 24h
* ARDS patient

Exclusion Criteria

* Pneumothorax drained or not
* Patient undergoing extracorporel mechanical oxygenation
* Patient who had a pneumonectomy partiel or total
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Urielle DESALBRES

Role: STUDY_DIRECTOR

Assistance Publique-Hôpitaux de Marseille

Antoine ROCH, MD/PhD

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique-Hôpitaux de Marseille

Locations

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Assistance Publique-Hôpitaux de Marseille

Marseille, , France

Site Status

Countries

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France

Other Identifiers

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2013-A00465-40

Identifier Type: OTHER

Identifier Source: secondary_id

2013-11

Identifier Type: -

Identifier Source: org_study_id