Open Suction vs. Closed Suction in ARDS

NCT ID: NCT05537974

Last Updated: 2023-01-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-15

Study Completion Date

2022-10-31

Brief Summary

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The alveoli tend to collapse in patients with ARDS. Endotracheal aspiration may increase alveolar collapse by decreasing the end-expiratory lung volume. The hypothesis is that closed endotracheal aspiration led to less end-expiratory volume loss when compared to open endotracheal aspiration.

Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This is a crossover study and suction procedure was made in a random order with 60 minutes wash out period between two suction maneuvers. Patients were randomized after intubation; randomization was made with sealed envelopes.

All patients mechanically ventilated with lung protective ventilation strategy. Before the suctioning the patients ventilated with 100% of oxygen for 60 seconds. In open suction, the patient was disconnected from mechanical ventilator, the aspiration catheter advanced until resistance met after that the catheter withdraw 1 cm before aspiration. During endotracheal suctioning a negative pressure applied two times for 5 seconds. The negative pressure was set 150 mmHg. All suctioning maneuvers performed by intensivists.
Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Open Suction

Endotracheal aspiration will perform after the patient disconnect from mechanical ventilation

Group Type OTHER

Endotracheal aspiration

Intervention Type PROCEDURE

Clearance of endotracheal secretions via a catheter.

Closed Suction

Endotracheal aspiration will perform without disconnection from mechanical ventilation

Group Type OTHER

Endotracheal aspiration

Intervention Type PROCEDURE

Clearance of endotracheal secretions via a catheter.

Interventions

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Endotracheal aspiration

Clearance of endotracheal secretions via a catheter.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Mechanically ventilated due to ARDS

Exclusion Criteria

Hemodynamically unstable Air leaks syndrome (pneumothorax) Higher level of FiO2 (\>60%) Chronic obstructive pulmonary disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Cenk Kirakli, M.D.

Professor Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Health Sciences Turkey, Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Intensive Care Unit

Izmir, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Yildirim S, Saygili SM, Sunecli O, Kirakli C. Comparison of the effects of open and closed aspiration on end-expiratory lung volume in acute respiratory distress syndrome. Korean J Anesthesiol. 2024 Feb;77(1):115-121. doi: 10.4097/kja.23194. Epub 2023 May 22.

Reference Type DERIVED
PMID: 37211764 (View on PubMed)

Other Identifiers

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IGHCEAH-ICU-7

Identifier Type: -

Identifier Source: org_study_id

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